Praziquantel Pharmaceutical Secondary Standard

Praziquantel Pharmaceutical Secondary Standard

Praziquantel is at present the only drug used for the treatment of human schistosomiasis. It has a pyrazino isoquinoline ring system and is found to be very successful in animals for its anticestode and antitrematode properties. It has been identified that the voltage-gated schistosome calcium ion (Ca 2+ ) channels serve as a target for praziquantel. Even though the commercial preparation of praziquantel comprises of equal amounts of both its ‘dextro′ and ‘laevo′ isomers, only the ‘laevo′ form exhibits schistosomicidal activity. Pharmaceutical secondary standards for application in quality control, provide pharma laboratories and manufacturers with a convenient and cost-effective alternative to the preparation of in-house working standards.

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Why Implement Pharmaceutical Secondary Standards?

Pharmaceutical secondary standards are crucial for quality assurance and control. They help ensure the consistency, efficacy, and safety of pharmaceutical products. Adopting secondary standards can significantly reduce time and costs related to the production and testing of drug substances. Moreover, they provide a reliable point of reference for pharma release testing, method development, and calibration, ensuring compliance with industry regulations.

Application

Praziquantel may be used as a pharmaceutical reference standard in the determination of the analyte in pharmaceutical preparations by electrochemical, spectrophotometric, and chromatographic techniques.

These Secondary Standards are qualified as Certified Reference Materials. These are suitable for use in several analytical applications including but not limited to pharma release testing, pharma method development for qualitative and quantitative analyses, food and beverage quality control testing, and other calibration requirements.

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